Objectives. To compare the analgesic efficacy of intrathecal clonidine and fentanyl added to bupivacaine after cesarean section.\r\nMethods. Ninety patients scheduled for cesarean section under spinal anesthesia were randomly allocated to one of the three\r\nfollowing groups to receive bupivacaine 10 mg combined with 75 ??g clonidine (group C), bupivacaine 10mg combined with 0.5mL\r\nfentanyl (group F), and bupivacaine 10mg combined with 0.5mL distilled water (group P), intrathecally. The time to first analgesic\r\nrequest, analgesic requirement in the first 24 hours after surgery, sensory and motor blockade onset time, duration of sensory\r\nand motor blockade, the incidence of hypotension, ephedrine requirements, bradycardia, and hypoxemia were recorded. Results.\r\nThe duration of anesthesia in clonidine group (275.10 �± 96.09) was longer compared to the placebo (211.73 �± 74.80) and fentanyl\r\n(192.33 �± 30.36) groups. This difference between group C versus F (P = 0.006) and P groups (P < 0.001) was significant. Similarly,\r\nthe mean time to first analgesic request was also longer in group C (519.44 �± 86.25) than in groups F (277.88 �± 94.25) and P\r\n(235.43 �± 22.35 min). This difference between group C versus F (P < 0.001) and P groups (P < 0.001) was significant. Conclusion.\r\nIntrathecal clonidine 75 �µg with bupivacaine prolonged the time to first analgesic request compared to fentanyl; however, the total\r\nanalgesic consumption within the first 24 h postoperative was similar in fentanyl and clonidine groups following cesarean section.\r\nThis trial is registered with ACTRN12611000909921 and ClinicalTrials.gov NCT01425658.
Loading....